Nucleic Acid Aptamer-Mediated Drug Delivery for Targeted Cancer Therapy (Aliyeva R)

Тематический план

• Cancer therapy
  

  Cancer therapy

  Today, cancer therapy is based primarily on chemotherapy and radiation, both of which have well-established side effects. Chemotherapy drugs typically kill not only cancer cells but also normal cells, and administration of bolus doses of these strong drugs can result in unpredictable side effects. One way of generating effective molecular probes to differentiate diseased cells is to use aptamers, that are capable of identifying molecular level differences between a healthy cell and a diseased cell
  

  • Aptamer−Drug Conjugates for Targeted Drug Delivery Лекция

    Aptamer−drug conjugates (ApDCs) have been developed to exploit aptamer-based targeted drug delivery. Current ApDC technologies largely rely on the noncovalent association of drug and specific DNA sequences,or complicated and less efficient organic synthesis.These technologies suffer from complicated preparation, low controllability of site-specific drug conjugation on vehicles, low synthesis yield in some cases, low drug loading capacity and the accompanying high cost and low spatiotemporal controllability in drug release
    

  • Aptamers Файл 903.4Кбайт документ PDF Загружено 8/04/18, 18:27
  • Aptamers in Cancer therapy Файл 1.5Мбайт Документ Word 2007 Загружено 6/04/18, 17:49
  • Video: A Smart Anti-tumor Drug Гиперссылка

    Nucleolin Aptamer-Paclitaxel Conjugate

    
    

  • Test: Aptamer Тест
  • Questions Задание
  • Reference Гиперссылка

    Aptamers in Cancer therapy 
• Thrombin Binding Aptamers
  

  Thrombin Binding Aptamers

  Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I
  
• Тема 3
  

  Тема 3