Nucleic Acid Aptamer-Mediated Drug Delivery for Targeted Cancer Therapy (Aliyeva R)

Aptamer−drug conjugates (ApDCs) have been developed to exploit aptamer-based targeted drug delivery. Current ApDC technologies largely rely on the noncovalent association of drug and specific DNA sequences,or complicated and less efficient organic synthesis.These technologies suffer from complicated preparation, low controllability of site-specific drug conjugation on vehicles, low synthesis yield in some cases, low drug loading capacity and the accompanying high cost and low spatiotemporal controllability in drug release